
Tyramine is a naturally occurring compound found in the body and in many foods and drinks, such as wine, cheese, and chocolate. It is a type of monoamine, a compound that the body relies on the enzyme monoamine oxidase to break down. High levels of tyramine in the body can cause several health problems, including migraine headaches and high blood pressure. Foods that are fermented, cured, pickled, aged, or spoiled tend to have high amounts of tyramine. Parmesan cheese is an aged cheese, and it is well-known that aged cheeses contain high levels of tyramine.
| Characteristics | Values |
|---|---|
| Does Parmesan cheese contain tyramine? | Yes, Parmesan cheese contains tyramine. |
| What is tyramine? | Tyramine is a naturally occurring trace amine derived from the amino acid tyrosine. |
| What are the effects of tyramine? | Tyramine can cause several health problems, the most common being migraine headaches. High levels of tyramine can also cause high blood pressure. |
| Which foods contain tyramine? | Fermented alcohol, aged cheeses, cured or processed meat, fermented or pickled vegetables, and some sauces. |
| Are there any alternatives to Parmesan cheese with lower tyramine levels? | Yes, American cheese, ricotta, cottage cheese, cream cheese, and fresh mozzarella are good alternatives with lower tyramine levels. |
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What You'll Learn
- Parmesan is an aged cheese, which typically contains high levels of tyramine
- Tyramine is a natural compound found in many foods and drinks
- It is produced by the metabolism of microorganisms during fermentation or decay
- High levels of tyramine in the body can cause migraines and high blood pressure
- People taking MAOIs should avoid foods with high tyramine content

Parmesan is an aged cheese, which typically contains high levels of tyramine
The production of tyramine in cheese is complex and depends on various factors, including the type of bacteria, storage duration, temperature, and salt concentration. Aged cheeses, such as Parmesan, tend to have higher tyramine levels than cheeses made from pasteurized milk, like American cheese, cottage cheese, ricotta, and cream cheese.
The interaction of tyramine in cheese with certain drugs, particularly monoamine oxidase inhibitors (MAOIs), can lead to a dangerous condition known as the "cheese effect" or "cheese reaction." People taking MAOIs are advised to avoid foods with high tyramine content, as the combination can cause a hypertensive crisis and other unwanted side effects.
In addition to aged cheeses, other foods that are fermented, cured, pickled, or spoiled tend to have high amounts of tyramine. These include fermented alcohol like beer, red wine, and some liqueurs, as well as certain types of sauces and tofu. People who experience migraines or have high blood pressure may benefit from reducing their tyramine intake by choosing fresh, unprocessed foods and alternative cheese options with lower tyramine levels.
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Tyramine is a natural compound found in many foods and drinks
Tyramine is found in a variety of foods, including cheese, wine, chocolate, and some fermented vegetables. Aged cheeses, such as Parmesan, have particularly high levels of tyramine. Other high-tyramine cheeses include Edam, Camembert, Cheddar, Swiss, Stilton, Gorgonzola, and Blue cheeses. Fermented alcohol, such as beer, red wine, vermouth, sherry, and some liqueurs, also contain high amounts of tyramine.
The presence of tyramine in food can be problematic for individuals taking monoamine oxidase inhibitors (MAOIs) for depression. Tyramine can cause a dangerous increase in blood pressure, known as the "'cheese effect'" or "cheese reaction," in people taking MAOIs. This reaction was first discovered by a British pharmacist who noticed that his wife, who was taking MAOIs, experienced severe headaches when eating cheese. Studies have also confirmed a link between dietary tyramine and migraines, and doctors often recommend a low-tyramine diet to patients prone to migraines.
Due to the potential health risks associated with tyramine, some countries have implemented regulations to control its sale and consumption. For example, tyramine is classified as a Schedule I controlled substance in Florida, where it is illegal to buy, sell, or possess without a license. However, enforcing this ban may prove challenging due to the presence of tyramine in many common foods and beverages.
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It is produced by the metabolism of microorganisms during fermentation or decay
Tyramine is a natural compound found in the body and in many foods. It is a type of compound called a monoamine and is derived from the amino acid tyrosine. It is produced by the metabolism of microorganisms during fermentation or decay. In cheese, lactic acid and enterococci bacteria produce relatively high amounts of tyramine. Enterococcus faecium, in particular, plays a major role in tyramine production.
The production of tyramine in cheese is a complex process that depends on several factors, including the bacterial strain, duration of storage, temperature, and salt concentration during storage. Molded cheeses, such as Gorgonzola, tend to contain higher amounts of tyramine than other varieties.
Aged cheeses, including Parmesan, are known to have high levels of tyramine. Other examples of aged cheeses with significant tyramine content are Edam, Camembert, Cheddar, Swiss cheese, Stilton, and Blue cheese. People who suffer from migraine headaches often choose to avoid tyramine-rich foods, as high levels of tyramine in the body can trigger migraines and lead to high blood pressure.
In addition to cheese, tyramine is commonly found in fermented foods and beverages. Fermented alcohol, such as beer, red wine, vermouth, sherry, and some liqueurs, contain high amounts of tyramine. Fermented or pickled vegetables, fermented soy products like soy sauce and tofu, and fermented condiments such as Worcestershire sauce and black bean sauce, are also sources of tyramine.
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High levels of tyramine in the body can cause migraines and high blood pressure
Parmesan cheese is one of the many foods that contain tyramine, a natural compound found in the body and in many foods. Other foods that contain high levels of tyramine include aged cheeses, fermented alcohol, citrus fruits, and cured meats.
High levels of tyramine in the body can cause several health problems, most commonly migraine headaches. People who suffer from migraines often choose to avoid foods containing tyramine, as it is a known trigger. Doctors have long recommended a low-tyramine diet to reduce the frequency of migraine attacks.
The link between tyramine and migraines was discovered in the 1950s when doctors began prescribing monoamine oxidase inhibitors (MAOIs) for depression. Some patients complained of headaches and symptoms of high blood pressure after eating foods high in tyramine. Studies have since confirmed the association between dietary tyramine and migraines.
Tyramine can trigger nerve cells to release norepinephrine, a hormone that increases blood pressure and heart rate. People who already have high blood pressure need to be careful when consuming foods with high tyramine levels. Additionally, people taking MAOIs should avoid foods with high tyramine content, as the combination can lead to serious side effects.
In summary, high levels of tyramine in the body can lead to migraines and high blood pressure, especially in individuals who are sensitive to tyramine or are taking certain medications such as MAOIs. A low-tyramine diet may be recommended to manage these conditions.
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People taking MAOIs should avoid foods with high tyramine content
Tyramine is a natural compound found in the body and in many foods, including wine, cheese, and chocolate. It is a type of monoamine, a compound that the body relies on the enzyme monoamine oxidase (MAO) to break down. Some people may not produce enough MAO to process tyramine, resulting in high tyramine levels. Certain medications, such as monoamine oxidase inhibitors (MAOIs), can also interfere with MAO production, making tyramine consumption dangerous.
Cheese, particularly aged cheeses like Parmesan, Edam, Camembert, Cheddar, and Swiss, contain high levels of tyramine due to the metabolism of microorganisms and the duration of storage. Molded cheeses such as Gorgonzola and Blue cheese also have significantly higher amounts of tyramine. Other foods with high tyramine content include fermented alcohol like beer, red wine, vermouth, sherry, and some liqueurs; fermented or pickled vegetables; and cured or processed meat.
If you are taking MAOIs, it is important to be mindful of the signs of increased blood pressure and seek medical attention if necessary. A low-tyramine diet is often recommended to reduce the frequency of migraine attacks and lower the risk of adverse effects from the medication.
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Frequently asked questions
Yes, parmesan cheese contains tyramine. All aged cheeses like parmesan, as well as other varieties such as Edam, Camembert, Cheddar, and Swiss cheese, are very high in tyramine.
Tyramine is produced in cheese due to the metabolism of microorganisms. Lactic acid and enterococci bacteria, especially Enterococcus faecium, produce relatively high amounts of tyramine. Molded cheeses such as Gorgonzola contain higher amounts of tyramine than other cheeses.
Tyramine can cause several health problems, most commonly migraine headaches. High levels of tyramine in the body can also lead to high blood pressure. People taking monoamine oxidase inhibitors (MAOIs) should be especially cautious as the combination of tyramine-rich foods and MAOIs can result in a hypertensive crisis.

























