
Annatto is a plant-based colouring derived from the seeds of trees native to Mexico and Brazil. It is frequently used to colour dairy products, such as cheese, due to its ability to bind easily to milk proteins. While annatto is marketed as a natural colour, it can cause adverse reactions in some individuals, such as headaches, irritability, restlessness, sleep disturbances, and allergic reactions. There is also limited research on the safety of annatto for pregnant or breastfeeding individuals, as well as those with diabetes, as it may interfere with blood sugar control. As such, it is important to be aware of the potential risks associated with annatto consumption and to consult a healthcare professional if you have any concerns.
| Characteristics | Values |
|---|---|
| What is Annatto | A plant, the seed and leaf of which are used to make medicine |
| How is it used | As a colouring agent in cheese and other foods |
| Side effects | Headaches, irritability, restlessness, sleep disturbance, hives, allergic reactions, irritable bowel syndrome, negative effects during pregnancy and breastfeeding, increase/decrease in blood sugar levels, reduced effectiveness of certain medications |
| Benefits | Antioxidant, antimicrobial, reduces risk of cancer, promotes eye health, helps manage age-related cardiac issues, improves bone health |
| Precautions | Avoid during pregnancy and breastfeeding, monitor blood sugar levels if diabetic, consult a doctor if taking medications that are broken down by the liver |
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What You'll Learn

Allergic reactions to annatto
Annatto is a plant whose seeds and leaves are used to make medicine. It is also used as a natural food colouring, producing colours from bright yellow to deep orange. It is commonly used in cheeses, snack foods, beverages, and cereals.
Although allergies to annatto are rare, they can occur. Some people with peanut or nut sensitivities have reported having reactions to annatto. Adverse reactions to annatto can include:
- Urticaria
- Angioedema
- Severe hypotension
- Aggressive tantrums
- Irritability
- Restlessness
- Sleep disturbances
- Headaches
- Anaphylactic shock
If you think you are allergic to annatto, consult your healthcare provider about allergy testing. If you are allergic to annatto, you will need to carefully read food labels to identify products that contain annatto and avoid them.
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Annatto's effect on blood sugar levels
Annatto is a plant whose seed and leaf are used to make medicine. It is also used as a colouring agent in food, including cheese.
Annatto contains chemicals that may change the way the body uses sugar. It may increase or decrease blood sugar levels, which can be dangerous for people with diabetes. If you have diabetes and are taking annatto as a medicine, it is important to monitor your blood sugar carefully and consult with a healthcare professional about your diabetes medication. This is because annatto may decrease the effectiveness of diabetes medications or increase the risk of your blood sugar going too low.
Some early studies on mice have shown that annatto-extracted tocotrienols (TT) can improve glucose homeostasis in high-fat diet-induced type 2 diabetic mice by decreasing the inflammatory response. However, more research is needed to determine the effectiveness of annatto in treating diabetes.
It is important to note that individual sensitivities to annatto may vary. Some people have reported negative reactions to annatto, including headaches, irritability, restlessness, sleep disturbances, and other food allergy symptoms. If you are taking any medications, especially those changed by the liver, it is important to talk to your healthcare provider before taking annatto, as it may interfere with the effectiveness of those medications.
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Annatto during pregnancy and breastfeeding
Annatto is a natural food colouring derived from the seeds of the achiote tree. It is used to colour cheese, butter, ice cream, and other food items. While annatto is considered safe for most people when consumed in moderation, there is limited research on its safety during pregnancy and breastfeeding.
During pregnancy, it is important to be cautious about what you eat as your body can be more prone to food sensitivities. There is limited information available on the safety of consuming annatto during pregnancy and breastfeeding. As a result, it is generally recommended to avoid annatto during these periods. Pregnant and breastfeeding individuals should be mindful of the potential risks and consult a healthcare professional if they have any concerns.
Annatto has been found to alter blood glucose levels in animal studies. This has raised concerns about its potential impact on diabetes management and blood sugar control during and after surgery. It is recommended to monitor blood glucose levels carefully if consuming annatto and to consult a doctor about any necessary adjustments to diabetes medication.
In addition to its potential impact on blood glucose levels, annatto may also trigger allergic reactions and cause or contribute to irritable bowel syndrome (IBS). A study found that a woman experienced IBS symptoms, including diarrhoea, abdominal pain, and bloating, after consuming food containing annatto. As annatto is not closely scrutinized by the FDA, it is important to be aware of these potential side effects and consume it in moderation.
When considering cheese consumption during pregnancy, it is generally recommended to avoid unpasteurized cheeses due to the risk of Listeria bacteria, which can cause listeriosis, a serious infection that pregnant individuals are particularly susceptible to. However, most pasteurized cheeses, including hard cheeses like cheddar and parmesan, semi-hard cheeses like edam and halloumi, and soft cheeses like feta, are considered safe to consume during pregnancy. Vegan cheeses are also generally safe, but it is important to consider their nutritional content and choose varieties made from simple, whole-food ingredients.
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Annatto's benefits
Annatto is a natural food colouring and spice derived from the seeds of the achiote tree (Bixa orellana). It is commonly used in cheese, butter, and snacks for its yellow to orange hue. Annatto has been linked to various health benefits, some of which are listed below:
Antioxidant Properties
Annatto is a natural source of antioxidants, which help protect your cells from damage caused by harmful molecules called free radicals. Free radicals have been linked to various diseases, including heart disease, diabetes, cancer, brain disorders, and Alzheimer's disease. The two main antioxidants in annatto are bixin and norbixin, which are plant pigments that give the seeds their distinctive red-orange colour.
Anti-inflammatory Properties
Annatto has been linked to reduced inflammation, which may help improve heart health and relieve muscle pain and soreness. In an animal study, supplementing with norbixin for three months reduced the accumulation of the compound N-retinylidene-N-retinylethanolamine (A2E), which has been linked to age-related macular degeneration (AMD).
Antimicrobial Properties
Annatto has been shown to slow the growth of disease-causing bacteria, including Staphylococcus aureus and Escherichia coli. It may also be effective against fungal infections caused by Candida utilis, Candida albicans, and Aspergillus niger.
Bone Health
Emerging research suggests that the tocotrienols in annatto may help preserve bone health by reducing bone resorption and improving bone formation.
Diabetes Management
Annatto might increase or decrease blood sugar levels, which could be beneficial for people with diabetes. However, it is important to monitor your blood sugar levels carefully if you are using annatto as a medicine and to consult with a healthcare professional before combining it with diabetes medication.
It is important to note that while annatto has been linked to these potential health benefits, more human studies are needed to fully understand its effectiveness and safety. Additionally, some individuals may experience negative reactions or allergic responses to annatto, especially those with known allergies to plants in the Bixaceae family.
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Annatto's side effects
Annatto is a plant whose seed and leaf are used to make medicine. It is also used as a natural food colouring, giving cheese its distinctive orange or yellow colour. While annatto has many health benefits, it may cause side effects in some people.
Some people may experience allergic reactions to annatto. These reactions can include hives, headaches, irritability, restlessness, sleep disturbance, and head banging in young children. In one case, a woman experienced IBS symptoms after consuming annatto, including diarrhoea, abdominal pain, and bloating.
Annatto may also affect blood sugar levels, which can be dangerous for people with diabetes. It is recommended that people with diabetes monitor their blood sugar levels carefully if they consume annatto and adjust the dose of their diabetes medication if necessary.
There is also some concern about the safety of taking annatto during pregnancy and breastfeeding. While there is not enough information to determine the safety of annatto during these periods, it is recommended that pregnant and breastfeeding women avoid consuming it to stay on the safe side.
Additionally, annatto may interact with certain medications that are broken down by the liver, such as chlorzoxazone, theophylline, and bufuralol. It is important to speak to a healthcare provider before taking annatto if you are taking any medications to ensure that it will not interfere with their effectiveness.
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Frequently asked questions
Annatto is a plant. The seed and leaf are used to make medicine. People take annatto for diabetes, diarrhoea, fevers, fluid retention, heartburn, malaria, and hepatitis. It is also used as a food colouring agent.
Annatto may trigger allergic reactions, cause irritable bowel syndrome, and cause negative effects during pregnancy and breastfeeding. It might also affect blood sugar levels and decrease the effectiveness of certain medications.
Annatto is commonly added to cheese, ice cream, butter, margarine, cakes, and packaged popcorn.
There is limited scientific information about the safety of annatto. While it is considered non-toxic and safer than most artificial food colourants, it may cause allergic reactions and other side effects in some individuals. If you are pregnant or breastfeeding, or taking medication, it is recommended to consult a healthcare professional before consuming annatto.

























